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작성자 :    comjesus
제목 :    활성산소(유해산소)의 종류
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1. 유해산소종(ROS: Reactive oxygen species)의 종류

유해산소종은 총 4가지로 분류될수 있다.

1) 산소래디컬(O2-)은 인체의 미토콘드리아와 인체가 스트레스를 받을 때 가장 많이 발생한다.

*음식물(Acetyl Co Enzyme A)가 미토콘드리아에서 Xanthin oxidase, aldehyde oxydase등의 효소의 작용을 받아 에너지원으로 산화가 될 때 산소가 필요한데 이 때 사용된 산소중 일부가 전자를 잃고 프리래디칼이 된다.

* 스트레쓰- 스트레쓰를 받으면 에핀에프린이 많이 나오면서 인체의 대사가 촉진된다.
촉진된 대사를 위해 산소의 소보가 많아지고 자연적으로 유해산소가 많아진다.
그러므로 스트레쓰를 받으면 유해산소로 인해 여러 가지 만성 질환에 걸릴 확률이 많아진다.


2) Singlet O2(1O2, 1중항 산소)

이 일중항 산소는 유리기중에서 가장 강력한 유리기이다.
산소가 자외선과 방사선을 받으면 산소 원자의 외곽을 돌고 있는 전자의 스핀이 불안해져서 전자는 안정적인 스핀을 가지지 못하고 불안정한 스핀을 가지게 되면서 이 산소는 유리기의 작용을 하게된다.
자외선을 많이 받는 부위인 피부에 주로 작용을 받아서 주름이 많이 생기고 기미와 주근개가 발생하는 원인이 된다.

3) H2O2(OH-, O2-)

대식세포즉 마크로파지는 인체에 돌아다니는 세균과 바이러스등을 잡아서 자기 몸속에 집어넣은후 과산화수소를 발생시며 이 이물질등을 살균시킨다.
이 때 발생하는 과다한 과산화수소도 유리기로 작용을 하고, 과산화수소가 작용하면서 발생시킨 OH-, O2-도 유리기로 작용을 하게된다.

4) ROO-(과산화지질)

* 음식물(말린 생선, 튀김종류, 산소와 접촉한 냉동식품등)등으로 이미 유리기를 섭취하는 경우

* 자외선을 받으면 안구이 불포화지방산이 산화되어 백내장이 된다.

* 일부의 의약품(당뇨약, 콜레스테롤 저하약, 항암제등)이 간에서 분해될 때 유리기 발생촉진

이렇게 위의 4가지 종류의 유리기가 우리 인체에서 발생하는 대부분의 질병의 원인이 된다.



2. 유리기의 작용과 질병

1) 혈관공격
유리기가 혈관을 공격하면 혈관의 염증, 혈관의 혈전, 모세햘관의 폐쇄의 순허로 발전한다.
모세혈관이 페쇄되면,
* 손발저림, 두통이 나타나고,

* 소화관 평활근에 영양공급이 부족하여 위무력증으로 인한 소화불량, 방광배 뇨근의 무력증으로 인한 뇨실금, 내장 하수로 인한 요통증상이 나타난다.

* 동맥경화가 되어 고혈압, 관상동맥질환의 원인이 되며

* 유리기로 인한 간동양혈관의 염증으로 바이러스가 침입한 것도 아닌데, 간의 수치가 높아지는 비바이러스성 간염이 된다.
그러므로 검사결과 바이러스는 없고 GOT, GPT의 수치가 높으면 유리기의 강력한 작용으로 생각하고 항산화제(카세롤)을 복용시켜야한다.

* DSCP 60개조세포의 손상과 기능저하로 당뇨증상, 알츠하이머, 전체의 노화가 진행된다.

2) DNA를 공격하고 DNA의 손상과 마모를 수리하는 기전을 공격하여 암의 유발을 촉진한다.

3) 항원 결정 인자를 공격
인체의 60조개 세포는 밖에서 침입하는 이물질과 자신을 구별하기 위하여 자신의 몸이라는 표식을 가지고 있다.
유리기가 각 세포의 이 표식을 공격해버리면 면역세포는 그 세포가 자신의 몸인지 밖에서 침입한 이물질인지 헷갈리게 되어 자신의 몸을 공격하여 자가면역질환을 유발하게 된다.
즉 인체의 자가면역질환은 인체의 모든 세포가 가지고 있는 항원결정인자를 공격하으모서 면역세포로 하여금 이물질을 구별할 수 없게하므로서 발생하는 질환이다.
자가면역질환으로는 가장 흔한 질환이 관절류마티이며, 입안이 잘 허는 베쳇, 대장궤양인 크론씨 병, 갑상선 기능 항진증, 강직성 척추염, 중증 근 무력증,
혈관염, 레이노우씨병, 눈이 건조한 지오그렌증후군등이 있다.

4) 피부의 노화
유리기가 피부의 콜라겐을 파괴하여 주름의 직접적인 원인이 된다.

5) 퇴행성 관절질환
관절의 활막과 활액을 공격하여 퇴행성 관절질환을 유발한다.
이처럼 각종 자가면역질환과 고혈압, 관상동맥폐쇄등의 심혈관질환, 소화관 무력증, 전립선비대, 배뇨근장애로 인한 뇨실금, 비 바이러스성 간염, 치매등 인체전체의 노화등에 유리기의 작용이 개입되고 있다.


3. 항산화제의 종류와 작용

이러한 유리기에 작용하는 항산화제는 항산화효소와 항산화비타민, 미네랄의 주가지로 대별된다.

1) 항산화효소 3가지

* SOD(Superoxide dismutase)
O2-에 반응하여 H2O2와 산소를 만들어서 유리기를 중화하는데, 이 때 발생된 H2O2는 산소유리기보다는 작용이 덜 하지만 이 자체도 유리기가 된다.
SOD는 망간, 아연, 구리등과 결합하여 항산화작용을 하며 구리는 또한 관절의 결합조직 구성성분이기도 하다.(Cu-SOD, Zn-SOD는 세포질에 존재, Mn-SOD는 미토콘드리아에 존재)
그러므로 관절류마티, 퇴행성 관절질환일 때는 구리, 아연, 망간이 함유된 항산화제인 비타몬을 사용하는 것이 좋다.

*Catalase와 Glutathionn peroxydase(Se함유)
이 두가지 효소는 과산화수소를 물로 만드는 작용을 한다.
글루타치온퍼옥시다제효소의 원료인 글루타민은 뮤셀티에 많이 함유되어 있고 셀레늄은 각종 항산화제에 많이 함유되어 있다.

2. 항산화비타민과 미네랄
* 비타민 E
세포막의 표면은 불포화 지방산으로 되어잇으므로 이 비타민E가 각종 항산화제의 세포막의 침투력을 높이므로 가장 기본적인 항산화제라 할수 있다.
세포의 불포화지방산의 산화를 보호하고 혈전생성을 억제하여 동맥경화등을 예방하고 혈류를 촉진한다.

* 베타카로텐
O2-를 제거하고 묜약세포의 활성을 증가하므로 각종 면역질환에 꼭 복용해야한다.
세균의 감염저항력을 증강하므로 감기가 잘 걸리거나 알러지, 염증이 잘 생기는 사람에게 꼭 필요하다.

* Se
비타민 E의 활성도를 증가시킥 혈관의 염증과 혈전을 저하하므로 혈관의 홍반, 피부홍반성 질환에 좋다.
항산화작용이 비타민E의 1970배정도되므로 꼭 복용하는 것이 좋다.

* 비타민C
대표적인 수용성 항 산화제이므로 많이 복용하는 것이 좋다.
단 비타민C자체도 환원이 되므로 알파리포익산을 복용하면 비타민 C를 인체가 재 활용할수 있다.
알파 리포익산은 그 자체가 강력한 항산화제역할을 하므로 당뇨환자등의 만성질환자에게는 꼭 복용을 권하는 것이 좋다.

* Cu, Mg
결합조직을 강화하는 작용이 있으므로 관절질환에는 이 성분이 함유된 비타몬이 우수하다.

* Cr(크롬)
당과 지방대사를 촉진하는 항산화제이므로 비만, 당뇨일 때는 꼭 셀크텐을 복용하는 것이 좋다.



4. 온누리 항산화제의 사용

* 카세롤- 일반적으로 모든 남자에게 적용하는 것이 좋다.
처음 하루 2캅셀(비타민 E의 용량이 800밀리그램)로 시작하여 두달 복용후보터 하루 3캅셀(비타민E용량 하루 1200밀리그램)로 복용하는 것이 좋다.

* 비타몬- 모든 여성들의 항산화제로 복용하는 것이 좋고 특히 관절질환(퇴행성이든 류마티이든)에 좋다.

* 셀업- 비타민 B1, B2, B6가 함유되어 있으므로 손발이 저리거나 근육통이 있는 사람의 항산화제로 적당하고 비타민 B2가 함유되어 잇으므로 식욕부진, 무기력한 사람의 항 산화제로 적당하다.

* 셀크텐- 심장기능저하(평소에 숨이 잘 차거나 두통이 있거나 가슴이 답답하거나), 비만, 당뇨증상이 있을 때 가장 좋은 항산화제이다.
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  jonn3<url>http://mentymanca.binhoster.com|index</url> <url>http://castmattbacon.binhoster.com|index</url> <url>http://tnorilurscul.binhoster.com|index</url> <url>http://nterelencei.binhoster.com|index</url> <url>http://chronsettdualsi.binhoster.com|index</url> <url>http://displewagarp.binhoster.com|index</url> <url>http://remtailesin.binhoster.com|index</url> <url>http://techkyocobarc.binhoster.com|index</url> <url>http://vernheseli.binhoster.com|index</url> <url>http://dispobadi.binhoster.com|index</url> <url>http://scaplusnithes.binhoster.com|index</url> <url>http://cacahapsti.binhoster.com|index</url> <url>http://contotihead.binhoster.com|index</url> <url>http://steepabducor.binhoster.com|index</url> <url>http://centcutabtigh.binhoster.com|index</url> <url>http://jaahostcounca.binhoster.com|index</url> <url>http://baclecoti.binhoster.com|index</url> <url>http://litiruckstam.binhoster.com|index</url> <url>http://loaremerri.binhoster.com|index</url> <url>http://iseccamar.binhoster.com|index</url> <url>http://abovtone.binhoster.com|index</url> <url>http://demulhuphe.binhoster.com|index</url> <url>http://neufalocua.binhoster.com|index</url> <url>http://kurobotsa.binhoster.com|index</url> <url>http://avraworvolg.binhoster.com|index</url> <url>http://nisdafurleu.binhoster.com|index</url> <url>http://silvelahlo.binhoster.com|index</url> <url>http://draginakiz.binhoster.com|index</url> <url>http://myeliteator.binhoster.com|index</url> <url>http://ovcutechling.binhoster.com|index</url> <url>http://brindougnessmi.binhoster.com|index</url> <url>http://scenconsfunsai.binhoster.com|index</url> <url>http://wardlicode.binhoster.com|index</url> <url>http://phtaminovdis.binhoster.com|index</url> <url>http://battredcuttper.binhoster.com|index</url> <url>http://isuntheterp.binhoster.com|index</url> <url>http://lessballlongrans.binhoster.com|index</url> <url>http://rilunanre.binhoster.com|index</url> <url>http://nforlealinza.binhoster.com|index</url> <url>http://erinfurce.binhoster.com|index</url> 02/05 23:10 x
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